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Search Results for " rar-related orphan receptor "

17

Compounds

Cat No. Product Name Synonyms Targets
T39250 Bevurogant ROR
Bevurogant is an antagonist of RORγt receptor and can be used in studies about the treatment of chronic inflammatory diseases.
T16832 S18-000003 ROR
S18-000003 is an effective orally bioavailable retinoic acid receptor-related orphan receptor-gamma-t inhibitor (IC50: 29 nM). S18-000003 inhibits IL-17 production.
T3S1251 Neoruscogenin ROR
1. Neoruscogenin represents a universal pharmacological tool for RORα research due to its specific selectivity profile versus other nuclear receptors.
T5163 SR1001 ROR
SR 1001 is an inverse agonist for RORα/RORγ (Kis: 172/111 nM).
T4670 SR0987 ROR
SR0987 is a RORγt agonist,
T4594 SR1078 SR 1078 ROR
SR1078 is an agonist of retinoic acid receptor-related orphan receptor (ROR)α/γ.
TQ0007 Cintirorgon LYC-55716 ROR
Cintirorgon (LYC-55716) is a selective, oral agonist of RORγ. Cintirorgon modulates gene expression of RORγ expressing T lymphocyte immune cells.
T7388 GSK805 ROR
GSK805 is a potent, orally bioavailable retinoid-related orphan receptor gamma t (RORγt) inverse agonist that interacts with the receptor's putative ligand binding domain without exerting significant effects on DNA bindi...
T2834 Nobiletin Hexamethoxyflavone Apoptosis , MMP , Reactive Oxygen Species , ROR , Autophagy
Nobiletin (Hexamethoxyflavone) is a natural polymethoxylated flavone isolated from citrus peels with anti-inflammatory and anti-tumor activities. Nobiletin is practically insoluble (in water) and an extremely weak acidic...
T9635 Cedirogant ABBV-157 ROR
Cedirogant (ABBV-157) is an orally active retinoid-related orphan receptor-γt(RORγt) inverse agonist that is used for psoriasis study.
T12753 RORγt Inverse agonist 6 ROR
RORγt Inverse agonist 6 is an agonist of RORγt inverse. RORγt Inverse agonist 6 can be used in research on Th17-driven autoimmune diseases.
T5160 SR3335 ML 176 ROR
SR3335 (ML 176) is a selective inverse agonist of RORα, competitively inhibiting the binding of 25-hydroxycholesterol to the ligand binding domain (Ki: 220 nM).
T9623 RORγt inverse agonist 13 ROR
RORγt inverse agonist 13 (Compound 3i) is a potent, orally active and selective RORγt inverse agonist (IC50=63.8 nM), with improved drug-like properties[1].
T14369 AZD-0284 ROR
AZD-0284 is an inverse agonist of the nuclear receptor RORγ. In development for the treatment of plaque psoriasis vulgaris and respiratory tract disorders[1].
T4050 GSK2981278 ROR gama modulator 1 ROR
GSK2981278 (ROR gama modulator 1) is a highly potent and selective inverse agonist of retinoic acid receptor-related orphan receptor gamma (ROR gamma).
T6690 T0901317 Apoptosis , FXR , Liver X Receptor , ROR
T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively; it inhibits nuclear factor/κB (NF/κB).
T13502 3-Oxo-5β-cholanoic acid Dehydrolithocholic acid ROR
3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid) (Dehydrolithocholic acid) is a bile acid metabolite and inhibits the differentiation of TH17 cells by directly binding to the key transcription factor RORγt (Kd: 1.13 μM)...
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